How long it takes for CBD to start working in your system depends on what way you consume it. Everyone has a biological system called your endocannabinoid system (ECS). The ECS is composed of endocannabinoids which influence your central nervous system (including the brain). It can take up to two weeks, or more, for your ECS to get going. Some people find that it starts to work after just 45 minutes! However, it’s hard to say because everyone is different. Most herbal remedies are slow releasing and therefore work best over a period of time with continuous use as part of a wholistic plan to health.